Edukemy Gazette

Hybrid Immunity

Hybrid Immunity

In News: A recent study in the journal The Lancet Infectious Diseases made observations on “hybrid immunity.”


  • Hybrid immunity is defined as the immune protection in individuals who have had one or more doses of a COVID-19 vaccine and experienced at least one SARS-CoV-2 infection before or after the initiation of vaccination
  • In simple words, hybrid immunity is gained from a previous infection plus vaccines – either the primary doses or both primary and booster doses.
  • Hybrid immunity offers a “higher magnitude and durability” of protection as compared to infection alone, emphasising the need for vaccination.

Key Findings

  • Protection against severe disease and hospitalisations from a Sars-CoV-2 infection alone was found to be 82.5% at three months after the last shot or infection.
  • This protection stood at 74.6% at 12 months and 71.6% at 15 months. Protection against reinfection declined faster, standing at 65.2% at three months and dropping to 24.7% at 12 months and 15.5% at 15 months.
  • In comparison, hybrid immunity with just the primary vaccine doses was found to be 96% at three months and 97.4% at 12 months. The same can offer 69% protection against reinfection at three months, dropping to 41.8% at 12 months.

Other Types of Immunities

Infection-induced immunity

 Vaccine-induced immunity

It is defined as the immune protection in an unvaccinated individual after one or more SARS-CoV-2 infections.

It is acquired through the introduction of a killed or weakened form of the disease organism through vaccination. 



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