Hybrid Immunity

Hybrid immunity is defined as the immune protection in individuals who have had one or more doses of a COVID-19 vaccine and experienced at least one SARS-CoV-2 infection before or after the initiation of vaccination
In simple words, hybrid immunity is gained from a previous infection plus vaccines – either the primary doses or both primary and booster doses.
Hybrid immunity offers a “higher magnitude and durability” of protection as compared to infection alone, emphasising the need for vaccination.

Key Findings

Protection against severe disease and hospitalisations from a Sars-CoV-2 infection alone was found to be 82.5% at three months after the last shot or infection.
This protection stood at 74.6% at 12 months and 71.6% at 15 months. Protection against reinfection declined faster, standing at 65.2% at three months and dropping to 24.7% at 12 months and 15.5% at 15 months.
In comparison, hybrid immunity with just the primary vaccine doses was found to be 96% at three months and 97.4% at 12 months. The same can offer 69% protection against reinfection at three months, dropping to 41.8% at 12 months.

Other Types of Immunities

Infection-induced immunity	Vaccine-induced immunity
It is defined as the immune protection in an unvaccinated individual after one or more SARS-CoV-2 infections.	It is acquired through the introduction of a killed or weakened form of the disease organism through vaccination.

Sources

https://indianexpress.com/article/explained/explained-health/hybrid-immunity-most-effective-against-severe-covid-study-8392858/

https://www.who.int/news/item/01-06-2022-interim-statement-on-hybrid-immunity-and-increasing-population-seroprevalence-rates

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