Here is Question No. 97 a part of our series on UPSC Prelims 2022.
Q97. Which one of the following statements best describes the role of B cells and T cells in the human body?
a) They protect the body from environmental allergens.
b) They alleviate the body’s pain and inflammation.
c) They act as immunosuppressants in the body.
d) They protect the body from the diseases caused by pathogens.
Answer – D
- Ptreg cells generation is influenced by a specific type of TCR signaling, and costimulation, and through cooperation with other signals, such as TGF-β, IL-2, and ATRA. These conditions suggest that pTreg cell differentiation could be restricted to precise locations such as mucosal surfaces where they may regulate immune responses to harmless antigens such as commensal microbiota and prevent allergic inflammation. Supporting these ideas, “studies using Rag-1-deficient T-B monoclonal mice sufficient or deficient in FOXP3 demonstrated that TCR transgenic pTreg cells were sufficient to establish mucosal tolerance and control allergic inflammation induced by the model antigen recognized by the TCR”
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