Fri, 22 Apr 2022

Warm Vaccines

  • Context: A heat-stable Covid-19 vaccine is being developed by the Indian Institute of Science (IISc) in Bengaluru and biotech start-up company Mynvax.
  • The vaccine needs no cold chain storage and has been observed to have generated strong antibody response against coronavirus variants, including Delta and Omicron, according to a study on mice.
  • The vaccine uses a part of the viral spike protein called the receptor-binding domain (RBD), which allows the virus to connect with the host cell to infect it.  
  • While most vaccines require refrigeration to remain effective, the heat-tolerant Covid-19 vaccine can be stored at 37 degrees Celsius for four weeks and at 100 degrees Celsius for up to 90 minutes.  
  • The heat tolerance of the vaccine and its ability to withstand transient thermal shocks is particularly promising to address the vaccine inequity that affects most low- and lower-middle-income countries.



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